Magnostics
Aurosphere Mesoporous Silica, Superparamagnetic Beads
Aurosphere Mesoporous Silica, Superparamagnetic Beads
Product description
Magnostics designed the Aurosphere® 800 mesoporous silica superparamagnetic beads for high‑performance nucleic acid separation workflows. Their specific surface area is over 40 times larger than that of conventional smooth silica beads (Fig 1), enabling enhanced interaction between nucleic acids and the silica surface.
This characteristic allows highly efficient binding of DNA and RNA (Fig 2), including short fragments down to ~50 bp (even~25 bp with optimized conditions) from serum, through adsorption within the pores and on the external silica surface (Fig 3).
They can be used directly for nucleic acid extraction or further adapted through chemical functionalization for a broad range of life science applications.
Features
- Specific surface area: ~160 m2/g (vs. ~3 m2/g for non-porous beads))
- Uniform size
- Uniform, thick silica coating
- Rapid, high efficiency separation
- Chemically inert - sterilizable
Specifications
| Nominal diameter | Nominal 1200 nm |
| Surface functional groups | Si-OH |
| Concentration | 10 mg/mL |
| Buffer | Water, 0.02% sodium azide |
Typical Applications
- RNA/DNA isolation for in vitro diagnostics, i.e., RT-qPCR
- Genome isolation – sequencing
- Ion exchange chromatography
- Chemical functionalization
Fig 1. Aurosphere® 800 nm mesoporousbeads (MB) have a significantly higher specific surface area compared to the conventional beads (CB).
Fig 2. Aurosphere® 800 nm mesoporous beads (streptavidin) extract 2x more biomarkers.
Circle: Mesoporous Beads
Triangle: Conventional Beads
Fig 3. Aurosphere® 800 nm mesoporous beads (MB) extract short fragments down to ~50 bp from serum (1) and ~25 bp with optimized conditions) (2) whereas conventional beads (CB) mostly only extract longer fragments (from >100 bp)
Documents
Product Description
Instructions for Use
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