Enabling early and accurate diagnosis of Ovarian Cancer
Our team has designed and validated a biomarker that allows early diagnosis.
By using Aurosphere® magnetic beads, we demonstrated that biomarker’s positive CTCs cells:
-enable rapid isolation and culture of CTCs.
-are a source of primary cells for the identification of the most effective chemotherapies, which can be done through tradition cell culture methods or genetic-proteomic analysis.
-can help distinguishing malignant from benign pelvic masses.
-can help to monitor a cancer’s response to a chemotherapy and detecting disease recurrence.
Illustration of the Circulating Tumor Cells (CTCs) isolation workflow from liquid biopsy obtained from cancer patient:
1.Sample and Wash: Blood for a liquid biopsy is drawn from patient and the cells are separated by centrifugation and resuspended in a reaction buffer.
2.Mix/Bind: Streptavidin Aurosphere® beads coated with suitable antibodies bind to the desired CTCs expressing antigen.
3.Wash: Following appropriate incubation period, use our magnetic separators to capture the cells.
4.Elute: Release the bound target CTCs from the streptavidin Aurosphere® beads with excess biotin
Isolated CTCs can be propagated and/or assessed in-vitro to enable precision cancer treatment for patients.
Are you interested in this nano-diagnostic?
Please contact us for further information.
Ovarian Cancer Cell Separationfor Screening and Staging DiagnosticsRead the publication
Targeting Mucin Protein Enables
Rapid and Efficient Ovarian Cancer Cell Capture: Role of Nanoparticle
Properties in Efficient Capture and Culture, Nathan Feely, Anita Wdowicz, Anne Chevalier, Ying Wang, Peng Li, Fanny Rollo ad Gil U. Lee, 2023